From Genetics Home Reference. Description Wilson disease is an inherited disorder in which excessive amounts of copper accumulate in the body, particularly in the liver, brain, and eyes. Frequency Wilson disease is a rare disorder that affects approximately 1 in 30, individuals. Inheritance This condition is inherited in an autosomal recessive pattern , which means both copies of the gene in each cell have mutations.
Research Studies from ClinicalTrials. References Aggarwal A, Bhatt M. Update on Wilson disease. Int Rev Neurobiol. A genetic study of Wilson's disease in the United Kingdom. Epub Mar Wilson's disease: an update. Nat Clin Pract Neurol. Citation on PubMed Ferenci P. Pathophysiology and clinical features of Wilson disease. Metab Brain Dis. Virchows Arch.
Normal liver vs. Share on: Facebook Twitter. Show references Shilsky ML. Wilson disease: Clinical manifestations, diagnosis and natural history. Accessed June 22, Wilson disease. Rochester, Minn. Pazirandeh S, et al. Overview of dietary trace minerals. Shilsky ML. Wilson disease: Treatment and prognosis. Bandmann O, et al.
Wilson's disease and other neurological copper disorders. The Lancet Neurology. American Liver Foundation. Riggin EA. AllScripts EPSi. If Wilson disease causes acute liver failure or cirrhosis with liver failure, you may need a liver transplant. If you have Wilson disease, talk with your doctor about your diet and foods that contain copper. When you start treatment for Wilson disease, your doctor may recommend avoiding foods that are high in copper, such as chocolate, liver, mushrooms, nuts, and shellfish.
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Diagnosis Doctors diagnose Wilson disease based on your medical and family history, a physical exam, an eye exam, blood tests, and urine tests.
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